Motor Neuron Death in ALS: Programmed by Astrocytes?
نویسندگان
چکیده
Motor neurons in ALS die via cell-autonomous and non-cell-autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al. (2014), in this issue of Neuron, discover that familial and sporadic ALS-derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis, suggesting a new therapeutic avenue.
منابع مشابه
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عنوان ژورنال:
- Neuron
دوره 81 شماره
صفحات -
تاریخ انتشار 2014